I agree with Kudu Fly into Cape town.Do a couple wine tours to the many Vineyards around the Cape, this should get rid of your jet lag & give you a feel for driving on the wrong side of the road!

Then do the trip to Port Elizabeth along the garden route.
If you want to go to the Kruger National Park, Book ahead In one of the many camps(self catering)& hire your own Vehicle,plan to spend at least 5 days in the park to make it worth it. Spending time in the park will also get your eyes used to the bush/veld witch will make your upcoming hunt easier. Your eyes need at least three days to become accustomed to the Veld!

While you are in Africa Fishing is fantastic check out some Tiger fish fishing!
If you are into Wing shooting send me a private message & I will put you in touch with the professionals!
Enjoy!