Just an observation from all the hunting shows or videos you see. They all take that same shot regardless where there are from. When you put a shell through the middle of a shoulder on say a mature bull moose whose fronts run 170lbs each and you knock out 20% due to blood shot it translates to 76lbs of normally very edible tasty meat. Too much waste for me. If the bull runs twenty or thirty yards and you salvage the 76lbs or knock it down on the spot, is it still worth saying it dropped on the spot. Besides out of all the moose I've shot behind the shoulder, I'd have to say that only one or two went more than ten yards. More times than not, they only take a couple strides and stand there for one in the neck or drop shortly after. They are not known for running off. A goat on the edge of a ridge is a different story though, because you want it down as quick as possible, then I would take the square on shoulder shot.