Killed a whitetail like that in 2009. Frontal shot, blew the valves off the heart, found the bullet in the pelvis. 300 win mag, 168 TTSX, about 100yrd shot. I have also shot a few antlerless elk in the head over the years, some with a 270 win, some with a 375 H&H, all have dropped instantly. All about the place and time for the shot, and the shooters confidence/abilities! I do like my broadside heart and lung, or spine shots though! Moosin