Yes, we've been with Trupanion for about 14 years now.
We do benefit from a "multiple pet" discount as we have 2 dogs and 1 cat with them and we did notice a decent premium reduction when we moved from Vancouver to Hope. Apparently they factor in local Vet prices in their premiums.
They were very, very easy to deal with on our pet claims, in particular during the almost 2 years of continuous bills for our dog's cancer treatment. Very quick to pay.